Jamie Lee Curtis

Curtis went on to achieve success as a comedic actress in Trading Places and A Fish Called Wanda, and she won a Golden Globe for her starring role in True Lies. She can be seen on the big screen this fall in the family film Beverly Hills Chihuahua. Married to Christopher Guest, the writer, director, and actor, Curtis is the mother of two young children and is also a successful children's author, with her eighth book due out in September.

Long praised as one of the most beautiful women in Hollywood, Curtis caused a stir in 2002 when she appeared in the pages of More magazine wearing no makeup and a less-than-flattering pair of shorts for a piece lampooning the film industry's superficial notions of beauty. And in her newest role, the 49-year-old proves that she's not afraid to tackle a subject that might make some squeamish: digestive health.

Everyday Health: You took a big risk in 2002 in More magazine's article, "True Thighs," in which you appeared in photographs without any makeup and wearing unflattering bicycle shorts. What was that like, and how did it affect your life afterward?